P130 Predictors of CPAP use in female OSA patients

Abstract Introduction It has been shown that quality of life (QoL) can be significantly improved in symptomatic female OSA patients when treated with CPAP. Therefore, we sought to understand the predictors of CPAP compliance in females. Methods A post-hoc analysis was conducted on data from a female specific OSA clinical trial. 122 female OSA patients (age 53.7 ± 9.5 years, BMI 32.8 ± 6.2 kg/m2, AHI 39.0 ± 18.2/h) from Germany and Spain had undertaken 3 months of CPAP treatment, with sleep and quality of life metrics collected pre and post CPAP usage. From the 111 patients who completed the study, 75/111 (67.6%) were compliant to CPAP (average usage ≥ 4 h/night). Logistic regression analyses were performed to investigate potential predictors of CPAP compliance, including demographics, comorbidities, sleep parameters, and pre-study quality of life. Results Predictors for CPAP compliance in female patients were increased age (p=0.0043), and higher ODI (p=0.0159). There were no relationships (p>0.05) found between CPAP compliance and comorbidities (anxiety, depression, diabetes, heart disease, hypertension, insomnia), or pre-study quality of life metrics (ESS, FOSQ, EQ-5D, PHQ scores). CPAP compliance was a significant factor in improvements in FOSQ and PH-Q scores, but not ESS scores. Discussion In this analysis we found that CPAP compliance strongly influenced QoL, measured by the FOSQ and PH-Q. Younger females, and those who have less severe oxygen desaturation indexes, may be more likely to struggle to reach CPAP compliance, and therefore may need additional support when starting CPAP.