The relationship between anticholinergic burden and frailty in the year preceding a diagnosis of dementia with Lewy bodies
Patients with newly diagnosed dementia with Lewy bodies (DLB) are more likely to have prescriptions for anticholinergic medications relative to patients newly diagnosed with Alzheimer's disease (AD) and older adults without documented cognitive impairment.In the year prior to a documented dementia diagnosis, 74% of patients with DLB and 66% of patients with AD had evidence of frailty.Anticholinergic medication burden was associated with frailty among all older adults in the study, including those without a dementia diagnosis.
Authors
- Rebecca C. Rossom (ORCID: https://orcid.org/0000-0002-9531-914X)
- Huong Nguyen (ORCID: https://orcid.org/0000-0002-5806-1178)
- Ann M. Werner
- Sotirios A. Parashos
- Michael J. Miller (ORCID: https://orcid.org/0000-0002-6026-6279)
- Joseph Kane (ORCID: https://orcid.org/0000-0002-8479-9977)
- Matthew J. Barrett (ORCID: https://orcid.org/0000-0003-4480-0221)
- Samuel J. Crowley (ORCID: https://orcid.org/0000-0002-3080-3950)
- John T. Schousboe (ORCID: https://orcid.org/0000-0002-9329-0750)
- Kathryn A Wyman‐Chick (ORCID: https://orcid.org/0000-0002-5057-5094)
- Lana Sargent (ORCID: https://orcid.org/0000-0001-5555-9985)
- Ella Chrenka (ORCID: https://orcid.org/0000-0002-3750-7062)
- Jennifer L. Kuntz (ORCID: https://orcid.org/0000-0002-0017-6853)
Institutions
- Kaiser Permanente (US)
- Medical University of South Carolina (US)
- Virginia Commonwealth University (US)
- Kaiser Permanente Center for Health Research (US)
- HealthPartners (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2024-10-01
- DOI
- https://doi.org/10.1002/dad2.70034
- Citations
- 2
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.69
Funders
- National Institutes of Health
- National Institute on Aging