Identification and Characterization of Acidic Degradation Products of Moxidectin Drug Substance Including Degradation Pathways Using LC, HRMS, and NMR
The HPLC method developed in this study significantly improves on existing USP/EP methods with regard to a separation of key impurities of (23Z)-moxidectin and 3,4-epoxy-moxidectin, offering robust performance for routine analysis of bulk moxidectin API batches and stability samples in quality control (QC) laboratories.
Authors
- Frank Rinaldi
- Tyler Huang (ORCID: https://orcid.org/0009-0004-7242-9743)
- Ayesha Nisathar
Institutions
- Eternity Bioscience (United States) (US)
Publication Details
- Journal
- Journal of AOAC International
- Published
- 2024-12-03
- DOI
- https://doi.org/10.1093/jaoacint/qsae096
- Primary Topic
- Helminth infection and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00