Trends and determinants of choline alfoscerate use in newly diagnosed Alzheimer's disease patients in Korea

Choline alfoscerate usage among newly diagnosed AD patients in Korea increased from 15.96% in 2012 to 47.65% in 2019.Male sex (OR = 1.05) and MedAid insurance coverage (OR = 1.07) were associated with higher odds of choline alfoscerate usage.Usage was more likely in patients with osteoarthritis (OR = 1.05) and less likely among those with hypertension (OR = 0.96), stroke/TIA (OR = 0.80), chronic kidney disease (OR = 0.80), and depression (OR = 0.93).Patients in rural areas had higher odds of using choline alfoscerate (OR = 1.28) compared to those in metropolitan areas (OR = 1.00).Despite limited evidence of efficacy, the extensive use of choline alfoscerate highlights the need for continuous monitoring and rigorous evaluation to ensure its safety and therapeutic value in AD management.