Activation of IP10/CXCR3 Signaling is Highly Coincidental with PrP <sup>Sc</sup> Deposition in the Brains of Scrapie-Infected Mice.
Our data demonstrate that the activation of IP10/CXCR3 signaling in prion-infected brain tissues coincides with PrP <sup>Sc</sup> deposition. Modulation of IP10/CXCR3 signaling in the brain represents a potential therapeutic target for mitigating the progression of prion diseases.
Authors
- Cao Chen (ORCID: https://orcid.org/0000-0002-5193-9283)
- Xiao‐Ping Dong (ORCID: https://orcid.org/0000-0002-1566-8447)
- Yue-Zhang Wu
- Dongdong Chen (ORCID: https://orcid.org/0009-0000-1368-485X)
- Lin Wang (ORCID: https://orcid.org/0000-0001-5716-6587)
- Jia Chen (ORCID: https://orcid.org/0000-0003-0080-0748)
- Wei Yang (ORCID: https://orcid.org/0000-0003-0198-1632)
- Qi Shi
- Chao Hu (ORCID: https://orcid.org/0000-0002-7129-8487)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Institute for Viral Disease Control and Prevention (CN)
Publication Details
- Journal
- PubMed
- Published
- 2024-11-20
- DOI
- https://doi.org/10.3967/bes2024.158
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00