Impact of Positive Airway Pressure on Right Ventricular Afterload in Pulmonary Arterial Hypertension
In PAH and healthy participants, CPAP had a modest effect on intrapleural pressures. The transmural haemodynamic changes of CPAP were modest with a net increase in pulmonary vascular compliance in both groups, but no change in resistive right ventricular afterload in the PAH group. The current study did not demonstrate any deleterious effects of CPAP on pulmonary haemodynamics.
Authors
- K. Hun Mok (ORCID: https://orcid.org/0000-0003-3663-2002)
- Clodagh M. Ryan (ORCID: https://orcid.org/0000-0002-2372-965X)
- Carolina Gonzaga (ORCID: https://orcid.org/0000-0001-8444-1222)
- Ewan C. Goligher (ORCID: https://orcid.org/0000-0002-0990-6701)
- John Thomas Granton (ORCID: https://orcid.org/0000-0002-2639-5958)
- Felipe Homem Valle (ORCID: https://orcid.org/0000-0001-7102-6644)
- Robert Francis Bentley (ORCID: https://orcid.org/0000-0002-5077-662X)
- Shaun Yo (ORCID: https://orcid.org/0000-0002-5670-0132)
- Susanna S Mak
Institutions
- Mount Sinai Hospital (CA)
- Harvard University (US)
- University of Toronto (CA)
- Toronto Rehabilitation Institute (CA)
- The Alfred Hospital (AU)
- Tan Tock Seng Hospital (SG)
- Pulmonary Hypertension Association (US)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1183/23120541.00796-2024
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Toronto
- Lung Health Foundation