Telomere length, in vivo Alzheimer’s disease pathologies and cognitive decline in older adults
Our finding suggests that older adults with relatively longer TL, particularly in the CI group, may have greater in vivo AD pathologies and experience more rapid cognitive decline, potentially mediated by brain tau deposition. Further studies are necessary to elucidate the biological links underlying these associations.
Authors
- Yu Kyeong Kim (ORCID: https://orcid.org/0000-0002-3282-822X)
- Jang-Seok Lee
- Keon Wook Kang (ORCID: https://orcid.org/0000-0003-2622-9017)
- Yun‐Sang Lee (ORCID: https://orcid.org/0000-0003-1640-2090)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Joon Hyung Jung (ORCID: https://orcid.org/0000-0003-1669-6113)
- Hyun‐Seob Lee (ORCID: https://orcid.org/0000-0001-6230-1405)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Jun Ho Lee (ORCID: https://orcid.org/0000-0002-1809-5154)
- Jun‐Young Lee (ORCID: https://orcid.org/0000-0002-5893-3124)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-5759-8969)
Institutions
- Seoul National University (KR)
- Seoul Metropolitan Government (KR)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- National University College (PR)
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1136/jnnp-2024-334314
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.33