Antibacterial Activity of Lemon IntegroPectin Against <i>Escherichia coli</i>

Abstract Lemon IntegroPectin sourced via hydrodynamic cavitation of lemon industrial processing waste in water only shows high antibacterial activity against Gram‐negative Escherichia coli . Insight on the antibacterial mechanism gained by investigating the oxidation kinetics of the phytocomplex at 0.5 mg/mL concentration in contact with the bacteria indicates that the oxidative stress, measured by reactive oxygen species (ROS) produced at the bacterial surface, is significantly higher than that generated by H 2 O 2 0.5 M. Given the nontoxic and mitoprotective nature of this bioconjugate sustainably extracted from an abundant biological resource, these findings are promising toward a new antimicrobial treatment against polymicrobial infections unlikely to develop drug resistance.