Characteristics of autoantibody-positive individuals without high-risk HLA-DR4-DQ8 or HLA-DR3-DQ2 haplotypes
Autoantibody-positive individuals who lack both high-risk HLA haplotypes (DRX/DRX) or have HLA-DR3-DQ2 but lack HLA-DR4-DQ8 (DR3/non-DR4) have phenotypic differences compared with DR3/DR4 and DR4/non-DR3 individuals, suggesting that there is aetiological heterogeneity in type 1 diabetes.
Authors
- Andrea K. Steck (ORCID: https://orcid.org/0000-0002-5931-9484)
- Richard A. Oram (ORCID: https://orcid.org/0000-0003-3581-8980)
- Kevan C. Herold (ORCID: https://orcid.org/0000-0003-1534-6613)
- MARIA JOSE REDONDO (ORCID: https://orcid.org/0000-0001-5871-4645)
- Todd M. Brusko (ORCID: https://orcid.org/0000-0003-2878-9296)
- Hemang M. Parikh (ORCID: https://orcid.org/0000-0002-9076-6709)
- Jay M. Sosenko (ORCID: https://orcid.org/0000-0002-7204-8367)
- David D Cuthbertson (ORCID: https://orcid.org/0000-0002-3785-9834)
- Mark A. Atkinson (ORCID: https://orcid.org/0000-0001-8489-4782)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- Jeffrey P. Krischer (ORCID: https://orcid.org/0000-0003-4526-888X)
- Suna Önengüt-Gümüşcü (ORCID: https://orcid.org/0000-0002-6563-8334)
Institutions
- University of Miami (US)
- Baylor College of Medicine (US)
- University of Exeter (GB)
- University of South Florida (US)
- Yale University (US)
- University of Florida (US)
- Texas Children's Hospital (US)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1007/s00125-024-06338-7
- Citations
- 6
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.30
Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development