Identification of Macrophage-Related Biomarkers for Abdominal Aortic Aneurysm Through Combined Single-Cell Sequencing and Machine Learning
Our findings highlight THBS1 as a potential driver of macrophage-mediated AAA formation and an important biomarker for AAA diagnosis. The study results would help in improving treatment outcomes in patients with AAA. These findings provide a foundation for the development of diagnostic tools and targeted therapies for AAA, potentially improving early detection and patient outcomes.
Authors
- Tiankuo Luan
- Xuemei Hu (ORCID: https://orcid.org/0000-0001-9009-0983)
- Daqiang Song
- Yu Zhao (ORCID: https://orcid.org/0000-0003-2632-7530)
- Guoqing Yao (ORCID: https://orcid.org/0000-0001-9369-6729)
- Jin Yao (ORCID: https://orcid.org/0000-0001-7567-3769)
- Deqing Chen (ORCID: https://orcid.org/0009-0003-4019-0224)
Institutions
- People's Hospital of Kaizhou District (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Rongcheng City People's Hospital (CN)
- First People's Hospital of Chongqing (CN)
- Chongqing Dazu District People's Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/jir.s499593
- Citations
- 4
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.68