Astaxanthin Increases Tumor Suppressor Gene Expression and Affects Cellular Biological Behavior in Oral Dysplastic Keratinocytes by Regulating <scp>DNA</scp> Methylation
This study confirmed significant differences in DNA methylation patterns among oral normal, dysplastic, and cancerous cells. Astaxanthin can reduce the promoter CpG methylation level of TSGs by reducing DNA methyltransferase 1 protein expression level, upregulating mRNA and protein expression, and subsequently modulating the biological behavior of DOK.
Authors
- Xiaofei Yu (ORCID: https://orcid.org/0009-0005-2892-9238)
- Peiyan Wang (ORCID: https://orcid.org/0000-0001-8914-1210)
- Yiqing Guo (ORCID: https://orcid.org/0000-0002-6119-414X)
- Mengyu Jiao
- Keqing Pan (ORCID: https://orcid.org/0000-0002-4376-0208)
- Zhaochen Liu (ORCID: https://orcid.org/0009-0004-8024-9590)
- Hui Zhang (ORCID: https://orcid.org/0000-0001-8726-7098)
- Jing Deng (ORCID: https://orcid.org/0000-0002-6632-2032)
- Jian Sun (ORCID: https://orcid.org/0000-0003-0368-4084)
- Pei Sun
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Journal of Oral Pathology and Medicine
- Published
- 2024-12-12
- DOI
- https://doi.org/10.1111/jop.13593
- Citations
- 5
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China
- Qingdao University