Eucalyptol (1.8-cineole) attenuates gentamicin-induced liver injury

Gentamicin (GM), which is in the aminoglycoside antibiotic class, is frequently preferred today in the treatment of diseases caused by gram-negative bacteria. However, its significant side effects on liver and kidney functions limit its clinical usefulness. The antioxidant and anti-inflammatory medical activities of eucalyptol (EUC, 1.8-cineole) have been reported in different studies. This study aimed to evaluate the effects of EUC on GM-induced hepatotoxicity. The study groups are consisted of control (C), EUC, GM and GM + EUC, and there were 7 rats in each group. At the end of the study, the rats were euthanized under appropriate conditions and samples were collected and biochemical, histopathological and immunohistochemical analyzes were performed. It was determined that there was a important increase in serum alanine aminotransferase (ALT), aspartate transferase (AST) and gamma-glutamyl transferase (GGT) enzymes in the GM group relative to the C group (p