Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study
The G-A haplotype, accompanied by latent low skeletal muscle mass and visceral obesity, led to the deterioration of insulin resistance over a 5 year period in this cohort, possibly through the altered expression of mitophagy-related genes.
Authors
- Yasuharu Tabara (ORCID: https://orcid.org/0000-0003-4505-7951)
- Daisuke Shiokawa
- Haruhiko Osawa (ORCID: https://orcid.org/0000-0003-0289-8363)
- Toshimi Hadate (ORCID: https://orcid.org/0000-0002-5479-477X)
- Yoshihiro Ogawa (ORCID: https://orcid.org/0000-0002-0834-2836)
- Misaki Takakado
- Isao Saito
- Yasunori Takata (ORCID: https://orcid.org/0000-0002-6530-4078)
- Yosuke Ikeda (ORCID: https://orcid.org/0000-0001-5568-2289)
- Jun Ohashi (ORCID: https://orcid.org/0000-0003-1765-1283)
- Ryoichi Kawamura (ORCID: https://orcid.org/0000-0003-3139-2046)
- Koutatsu Maruyama
Institutions
- Kyushu University (JP)
- Oita University (JP)
- Kyoto University (JP)
- Ehime University (JP)
Publication Details
- Journal
- Diabetologia
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1007/s00125-024-06322-1
- Citations
- 2
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- Japan Association for Diabetes Education and Care
- Research Promotion Foundation
- Japan Society for the Promotion of Science