Նախածննդյան իմուն-կախյալ կենսացուցիչների հնարավոր ախտածին ազդեցությունը աուտիզմի սպեկտրի խանգարումների զարգացման վրա

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and interaction, as well as restricted or repetitive behaviors. In addition to the dominant genetic factors, epigenetics is also considered as a causative component, i.e. family diseases, external harmful substances, toxins, drugs, etc. In particular, the model of maternal autoantibody-mediated autism spectrum disorders, which has been around for decades, but is still considered new, considers maternal antibodies that bind to intracellular proteins in the fetal brain and disrupt their activity as a causal factor. Prenatal biomarkers are also the changes in the cytokine spectrum that occur during infectious diseases of the mother, the damaging effect of which is observed due to the cytokine receptors present in the fetal brain tissue, maternal and familial autoimmune diseases, in which statistics shows a risk of burden on the offspring, and the analysis data shows more cases of ASD in similar families as compared to healthy families. It is appropriate to study the described causative factors as prenatal biomarkers. This period is considered to be the most unknown period, full of risk factors for the fetus, since the unprotected and still unformed body of the fetus can undergo epigenetic changes.