Synthesis of continuously substituted quinolines from <i>o</i>-alkenyl aromatic isocyanides by palladium-catalyzed intramolecular imidoylative 6-<i>endo</i> cyclization
An efficient synthesis of continuously substituted quinoline derivatives <i>via</i> palladium-catalyzed intramolecular 6-<i>endo</i> imidoylative cyclization of <i>o</i>-alkenyl aryl isocyanides with (hetero)aryl halides or vinylic triflates has been developed. The reaction proceeds through the concerted metalation-deprotonation (CMD) mechanism by activation of a vinyl C-H bond with imidoylpalladium assisted by the carboxylate.
Authors
- Tuanli Yao (ORCID: https://orcid.org/0000-0003-2905-6596)
- Wei Liu (ORCID: https://orcid.org/0000-0002-7825-4399)
- Xiangyang Qin (ORCID: https://orcid.org/0000-0001-6237-1876)
- Hanfu Hu
Institutions
- Shaanxi University of Science and Technology (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1039/d4cc05461j
- Citations
- 4
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 1.00