Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody
Our findings suggest that there is an optimal dose range for the abscopal effect generated with the CIRT combined with anti-CTLA4 antibody, and it highlights a new opportunity for increased induction efficiency of the abscopal effect of combination therapy.
Authors
- Liqiu Ma (ORCID: https://orcid.org/0000-0001-6597-6061)
- Kazuhiro Kakimi (ORCID: https://orcid.org/0000-0003-2631-3040)
- Kensuke Osada
- Yukari Yoshida (ORCID: https://orcid.org/0000-0001-7817-2142)
- Takashi Shimokawa (ORCID: https://orcid.org/0000-0001-6549-9277)
- Akihisa Takahashi (ORCID: https://orcid.org/0000-0002-9960-2153)
- Gang Guo (ORCID: https://orcid.org/0000-0002-1714-9034)
- Li Sui (ORCID: https://orcid.org/0000-0001-9379-1080)
- Lin Xie (ORCID: https://orcid.org/0000-0002-6472-322X)
- Saaya Suzuki
- Jialing Wen
- Wangcai Ren
- Yang Li (ORCID: https://orcid.org/0009-0004-3740-097X)
- Yoshimitsu Sakamoto
Institutions
- China Institute of Atomic Energy (CN)
- National Institutes for Quantum Science and Technology (JP)
- Gunma University Hospital (JP)
- Kindai University (JP)
Publication Details
- Journal
- Neoplasia
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.neo.2024.101099
- Citations
- 6
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 2.43
Funders
- China Institute of Atomic Energy
- China National Nuclear Corporation
- Japan Society for the Promotion of Science