Blood-based sex-differential DNA methylation in Alzheimer’s disease
Aim: We aim to explore the blood-based sex-differential DNA methylation profiles in patients with Alzheimer’s disease (AD). Methods: The same analytical pipeline and meta-analysis procedure were applied to 254 patients with AD and 261 matched healthy controls (HC) from four blood-based datasets to identify sex-differentially methylated positions (sex-DMPs) and their biological functions. We further reviewed brain-based sex-DMPs previously reported in AD and intersected with blood-based sex-DMPs. Results: We identified 134 sex-DMPs in AD, 88 were unique to AD, and 46 were shared with HC. Eleven novel sex-DMPs and 28 sex-DMPs consistent across blood and brain were recognized for the first time. Differentially methylated genes, such as COL25A1 , MSUT2 , ELAVL4 , SLC17A7 , EPHA4 , and PPP2CB , were closely related to the pathogenesis of AD. In addition, immune-related processes were enriched in the enrichment analysis. Conclusion: Sex-differential DNA methylation in blood provides potential biomarkers for AD pathogenesis, and also points to potential drug targets for precision medicine.
Authors
- Tianmi Yang
- Yi Xiao (ORCID: https://orcid.org/0000-0001-7274-6774)
- Huifang Shang (ORCID: https://orcid.org/0000-0003-0947-1151)
- Chunyu Li
- Qianqian Wei (ORCID: https://orcid.org/0000-0002-7825-5498)
- Yangfan Cheng (ORCID: https://orcid.org/0000-0001-6315-8647)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Ageing and Neurodegenerative Diseases
- Published
- 2024-12-13
- DOI
- https://doi.org/10.20517/and.2024.28
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.47
Funders
- University of Exeter
- National Natural Science Foundation of China
- Universidade de Macau
- University of California, Los Angeles