Biomimetic prebiotic synthesis of homochiral peptides <i>via</i> a potential 5′-aa-AMP precursor
Inspired by biosynthetic peptides, we investigate the chiral recognition properties of adenylate amidate (<i>N</i>-aa-AMP, a potential analog of 5'-aa-AMP) in prebiotic peptide formation. Our findings demonstrate that <i>N</i>-L-aa-AMP preferentially binds to L-aa, facilitating the formation of homochiral peptides, while <i>N</i>-D-aa-AMP shows a preference for D-aa, thereby achieving homochirality in peptide synthesis. Collectively, these results enhance our understanding of the evolutionary origins of homochirality on prebiotic Earth.
Authors
- Dingwei Gan (ORCID: https://orcid.org/0000-0002-4257-2213)
- Dongru Sun (ORCID: https://orcid.org/0000-0002-1000-2363)
- Min Zhang (ORCID: https://orcid.org/0000-0001-7683-1802)
- Jianxi Ying (ORCID: https://orcid.org/0000-0002-1035-5345)
- Xiaofan Guo (ORCID: https://orcid.org/0000-0002-7220-5094)
- Yufen Zhao (ORCID: https://orcid.org/0000-0003-3560-435X)
- Shoujun Wang (ORCID: https://orcid.org/0000-0003-0956-792X)
- Li Zhang (ORCID: https://orcid.org/0000-0002-8502-4946)
Institutions
- Ningbo University (CN)
- Xiamen University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1039/d4cc05580b
- Primary Topic
- Origins and Evolution of Life
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences