<scp>miR</scp>‐130a‐3p enhances autophagy through the <scp>YY1</scp>/<scp>PI3K</scp>/<scp>AKT</scp>/<scp>mTOR</scp> signaling pathway to regulate macrophage polarization and alleviate diabetic retinopathy
miR-130a-3p inhibited the activation of the PI3K/Akt/mTOR pathway by downregulating YY1 expression, thus facilitating macrophage autophagy, inhibiting M1 polarization and the inflammatory response of macrophages, and finally attenuating the progression of DR. The results of this study provide theoretical support for the use of miR-130a-3p as a new target for the treatment of DR.
Authors
- Jia Ma (ORCID: https://orcid.org/0000-0002-5621-8645)
- Qianbo Chen (ORCID: https://orcid.org/0009-0002-0541-1522)
- Xiaoting Xi
- Yaxian Song
- Yan Li (ORCID: https://orcid.org/0000-0002-9897-5548)
- Yuxin Zhang (ORCID: https://orcid.org/0000-0002-5144-0693)
- Xuewei Wang (ORCID: https://orcid.org/0000-0003-3679-7421)
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1111/jdi.14381
- Citations
- 9
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.48
Funders
- Kunming Medical University
- Yunnan Provincial Science and Technology Department