Synthesis of 1,4,2-Diazaphospholidine-3,5-diones Using Na(OCP) as the “P” Source
A refined synthesis of 1,4,2-diazaphospholidine-3,5-dione derivatives was achieved through a cyclization reaction involving Na(OCP) and isocyanates. Na(OCP) was demonstrated to be a relatively stable and safe source of phosphorus, enabling the production of diverse 1,4,2-diazaphospholidine-3,5-dione derivatives with high yields. The reaction proceeds efficiently under catalyst-free and mild conditions. Both experimental findings and density functional theory calculations have elucidated that the process involves a crucial step of carbon monoxide elimination, which provides deeper insight into the reaction mechanism.
Authors
- Dongping Chen (ORCID: https://orcid.org/0009-0009-9848-2557)
- Xi‐Cun Wang (ORCID: https://orcid.org/0000-0003-3770-9817)
- Yaling Tian
- Wenbo Xu (ORCID: https://orcid.org/0000-0002-2389-0275)
- Zhibin Wang (ORCID: https://orcid.org/0000-0001-5602-1669)
- Yao Chai (ORCID: https://orcid.org/0000-0002-0967-7945)
- Zheng‐Jun Quan (ORCID: https://orcid.org/0000-0002-4393-3594)
- Bo Yang (ORCID: https://orcid.org/0000-0001-5586-3186)
Institutions
- Northwest Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1021/acs.joc.4c02259
- Citations
- 1
- Primary Topic
- Organophosphorus compounds synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.25
Funders
- Northwest Normal University
- National Natural Science Foundation of China