Multi-omics analysis-based clinical and functional significance of a novel prognostic and immunotherapeutic gene signature derived from amino acid metabolism pathways in lung adenocarcinoma
In patients with LUAD, the PTAAMG-Sig effectively predicted OS, drug sensitivity, and immunotherapy outcomes. These findings are expected to provide new targets and strategies for personalized treatment of LUAD patients.
Authors
- Feifei Wei (ORCID: https://orcid.org/0000-0002-5770-3255)
- Asami Hagiwara (ORCID: https://orcid.org/0000-0002-9713-0113)
- Tomoyuki Tagami
- Yohei Miyagi
- Haruhiro Saito (ORCID: https://orcid.org/0000-0002-8541-8339)
- Yuka Igarashi (ORCID: https://orcid.org/0000-0002-7270-2285)
- Yoshiro Nakahara (ORCID: https://orcid.org/0000-0001-5579-4491)
- Huihui Xiang (ORCID: https://orcid.org/0000-0002-1229-7695)
- Shiro Koizume (ORCID: https://orcid.org/0000-0002-9132-5286)
- Shinya Sato (ORCID: https://orcid.org/0000-0002-2155-2379)
- Rika Kasajima (ORCID: https://orcid.org/0000-0001-6389-6594)
- Tetsuro Sasada (ORCID: https://orcid.org/0000-0003-3262-8559)
- Tatsuma Ban (ORCID: https://orcid.org/0000-0001-9517-9661)
- Tomohiko Tamura (ORCID: https://orcid.org/0000-0002-9664-1747)
- Yoshiyasu Nakamura
- Koichi Azuma
- Mitsuyo Yoshihara
Institutions
- Kurume University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- Ajinomoto (Japan) (JP)
- Kanagawa Cancer Center
- Kitasato University (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-12-13
- DOI
- https://doi.org/10.3389/fimmu.2024.1361992
- Citations
- 9
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.10
Funders
- Japan Agency for Medical Research and Development
- University of Tokyo
- Japan Society for the Promotion of Science