Impact of Repeated Variant Exposures on Cellular and Humoral Immunogenicity Induced by SARS-CoV-2 Vaccines
Overall, mRNA-based vaccines exhibited stronger long-term immunogenicity. Repeated exposure to the Omicron variant seems to mitigate immune imprinting from the wild-type SARS-CoV-2. An association was observed between high antibody levels and a strong cellular response, although the correlation was not linear.
Authors
- José Luís del Pozo (ORCID: https://orcid.org/0000-0002-5402-3334)
- Alejandro Fernández‐Montero (ORCID: https://orcid.org/0000-0002-8741-7401)
- Álvaro González (ORCID: https://orcid.org/0000-0002-1423-273X)
- Leire Fernández-Ciriza (ORCID: https://orcid.org/0000-0002-1874-8338)
- Silvia Carlos (ORCID: https://orcid.org/0000-0002-4968-7080)
- Gabriel Reina (ORCID: https://orcid.org/0000-0003-4079-9753)
- Francisco Carmona-Torre (ORCID: https://orcid.org/0000-0002-8281-9583)
- Marta Vidaurreta (ORCID: https://orcid.org/0000-0002-6003-3774)
- Nazaret Betanzos
Institutions
- Navarre Institute of Health Research (ES)
- Clinica Universidad de Navarra (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Vaccines
- Published
- 2024-12-13
- DOI
- https://doi.org/10.3390/vaccines12121408
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00