Non-tumor associated Psammoma bodies in cervical lymph node: A case report

Psammoma Bodies (PBs), associated with thyroid carcinomas, raise diagnostic challenges when found without concurrent papillary thyroid carcinoma (PTC). This report presents a case of PBs in cervical lymph nodes without evidence of thyroid malignancy. A 53-year-old woman with neck swelling underwent total thyroidectomy. Despite PBs in cervical lymph nodes, microscopic examination revealed thyroid follicular nodular disease with no evidence of PTC. This case questions the diagnostic reliability of PBs without PTC. The study by Hunt et al. emphasized the potential for PTC detection in cases initially labeled as PBs-only, stressing the need for comprehensive evaluation. Differential diagnoses and the need for clinical correlation highlight the complexity of interpreting PBs without PTC. Seeking a second opinion and additional diagnostic tools may be crucial. PBs, despite their strong link to PTC, may not conclusively indicate malignancy when found alone. Management decisions should consider clinical context, patient history, and available diagnostic tools. Further exploration of PBs in benign thyroid conditions is encouraged for improved understanding and diagnostic accuracy in larger series. Collaborative efforts between pathologists and clinicians are essential for optimal patient care in such challenging cases.