“A COMPREHENSIVE REVIEW OF THE INCREASE IN THYROID DISEASE CASES DUE TO THE COVID-19 PANDEMIC”

COVID-19is the pandemic of the new millennium, SARS-CoV-2, the virus responsible for COVID-19, has been associated with numerous post-infection complications.COVID-19 may result in systemic and pulmonary inflammation, which may have an impact on the function of multiple organs. Information about how COVID-19 and thyroid have emerged and are growing more quickly since March 2020.The virus that infects the thyroid gland and its function is well known to interact intricately with linked inflammatory-immune responses.SARS-CoV-2 combines ACE2 with Trans membrane protease 2 (TMPRSS2) is the essential molecular complex that infects host cells. Remarkably, ACE2 and the thyroid gland expresses TMPRSS2 at higher levels than the lungs do. Our review of the literature revealed more evidence that the entire hypothalamic-pituitary-thyroid (HPT) axis and the thyroid gland may be relevant targets of damage by SARS-CoV-2.To be more precise, thyroid disorders associated with COVID-19 include thyroid toxicosis, hypothyroidism, and nonthyroidal illness syndrome.