Hypothermia therapy in neonatal hypoxic-ischemic encephalopathy: Current perspectives, combination therapy and future directions

Hypoxic-ischemic encephalopathy (HIE) in neonates, resulting from oxygen deprivation during birth, is a significant cause of death and long-term disabilities. Therapeutic hypothermia has emerged as a pivotal intervention for improving neurological outcomes in infants with HIE. This review aims to summarize current practices, outcomes, and challenges of hypothermia therapy in neonatal HIE, and adjuvant therapies, along with future directions in this evolving field.