An outbreak of influenza A(H1N1)pdm09 antigenic variants exhibiting cross-resistance to oseltamivir and peramivir in an elementary school in Japan, September 2024
An outbreak of influenza A(H1N1)pdm09 viruses exhibiting cross-resistance to oseltamivir and peramivir occurred in Yokohama, Japan, in September 2024. Among 24 students in a class, 11 were diagnosed with influenza or influenza-like illness, and viruses harbouring the NA H275Y and HA Q210H substitutions were isolated from four. Deep sequencing analysis confirmed the clonal spread of these mutants. Antigenic analysis revealed differences from the vaccine strain. Continued monitoring is crucial to assess the potential for further spread of these mutant viruses.
Authors
- Hideka Miura
- Hiroko Morita
- Shuzo Usuku
- Yoshimasa Takahashi (ORCID: https://orcid.org/0000-0001-6342-4087)
- Masataka Ichikawa
- Yoko Matsuzaki (ORCID: https://orcid.org/0000-0003-2757-5886)
- Emi Takashita (ORCID: https://orcid.org/0000-0002-9064-4699)
- Kazuya Nakamura (ORCID: https://orcid.org/0000-0003-4113-1579)
- Ichiro Okubo
- Hideki Hasegawa (ORCID: https://orcid.org/0000-0002-6558-2297)
- Shiho Nagata
- Seiichiro Fujisaki (ORCID: https://orcid.org/0000-0002-6129-8950)
- Masayuki Shirakura
- Shinji Watanabe
- Noriko Kishida (ORCID: https://orcid.org/0000-0003-4501-568X)
- Ryuichi Senda
- Kohei Shimizu
Institutions
- Yamagata University (JP)
- National Institute of Infectious Diseases (JP)
- Kanagawa Prefectural Institute of Public Health (JP)
Publication Details
- Journal
- Eurosurveillance
- Published
- 2024-12-12
- DOI
- https://doi.org/10.2807/1560-7917.es.2024.29.50.2400786
- Citations
- 4
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Ministry of Health, Labour and Welfare