Identification and Evaluation of Angiogenesis-Related Proteins That Predict Major Adverse Cardiovascular Events in Patients with Peripheral Artery Disease
Among a panel of 22 angiogenesis-related proteins, endostatin, ANGPTL4, and ANGPTL3 were identified to be independently and specifically associated with 2-year MACEs in patients with PAD. Measurement of plasma concentrations of these proteins can support MACE risk stratification in patients with PAD, thereby informing clinical decisions on multidisciplinary referrals to cardiologists, neurologists, and vascular medicine specialists and guiding aggressiveness of medical treatment, thereby improving cardiovascular outcomes in patients with PAD.
Authors
- Batool Abuhalimeh
- Jason Chin
- Mohammad Qadura (ORCID: https://orcid.org/0000-0003-0893-9920)
- Rawand Abdin
- Abdelrahman Zamzam (ORCID: https://orcid.org/0000-0003-3291-5902)
- Ben Li (ORCID: https://orcid.org/0000-0002-7191-1034)
- Khurram Rasheed (ORCID: https://orcid.org/0009-0006-9966-8490)
- Houssam Younes
- Farah Shaikh
Institutions
- St. Michael's Hospital (CA)
- University of Toronto (CA)
- McMaster University (CA)
Publication Details
- Journal
- Journal of Cardiovascular Development and Disease
- Published
- 2024-12-13
- DOI
- https://doi.org/10.3390/jcdd11120402
- Citations
- 1
- Primary Topic
- Lipid metabolism and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.40
Funders
- University of Toronto