5MO Novel radiologic phenotypes of chaotic tumor angiogenesis associated with poor ICI outcomes in NSCLC
VEGF and immune checkpoint inhibitor (ICI) combination treatments have recently shown efficacy in non-small cell lung cancer (NSCLC), highlighting the role of tumor vasculature in outcomes. Conventional biomarkers focus on genetic or immune factors, but overlook the vascular complexity of tumors. We discovered two Imaging Tumor Angiogenesis Phenotypes (ITAP) in patients with advanced NSCLC associated with overall survival (OS) and progression-free survival (PFS).
Authors
- Rhea Chitalia (ORCID: https://orcid.org/0000-0001-7880-930X)
- Anant Madabhushi (ORCID: https://orcid.org/0000-0002-5741-0399)
- Carla Leibowitz
- Vamsidhar Velcheti (ORCID: https://orcid.org/0000-0002-6589-0759)
- Nathaniel Braman (ORCID: https://orcid.org/0000-0001-5603-0821)
- Kai Zhang (ORCID: https://orcid.org/0000-0003-4237-3115)
Institutions
- Emory University (US)
- NYU Langone Health (US)
- Community Health Partnership (US)
- Artificial Intelligence in Medicine (Canada) (CA)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.iotech.2024.100889
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ida Montinin Säätiö
- Helsingin Yliopisto
- Jane ja Aatos Erkon Säätiö
- Syöpäsäätiö