Pharmacological Blockade of Group II Metabotropic Glutamate Receptors Reduces the Incidence of Brain Tumors Induced by Prenatal Exposure to N-ethyl-N-nitrosourea in Rats
Tumors in both groups of rats showed a moderate/high expression of the astrocyte marker, GFAP, and the oligodendrocyte marker, OLIG-2, and a low expression of the proliferation marker, Ki-67. However, tumors of the ENU + LY341495 group showed a reduced density of Iba-1+ cells, suggesting a lower extent of neuroinflammation in the tumor microenvironment. These findings strengthen the hypothesis that mGlu3 receptors are candidate drug targets for the treatment of malignant gliomas.
Authors
- Matteo Caridi
- Maria Antonietta Oliva (ORCID: https://orcid.org/0000-0003-3460-696X)
- Sabrina Staffieri (ORCID: https://orcid.org/0000-0001-8756-5028)
- Antonietta Arcella (ORCID: https://orcid.org/0000-0002-0708-8282)
- Anna Traficante (ORCID: https://orcid.org/0000-0001-9545-6542)
- Marika Alborghetti (ORCID: https://orcid.org/0000-0001-9327-6660)
- Veronica Russo (ORCID: https://orcid.org/0009-0003-1705-2448)
- Giuseppe Battaglia (ORCID: https://orcid.org/0000-0001-7571-3417)
Institutions
- University of Perugia (IT)
- Istituto Neurologico Mediterraneo (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Current Neuropharmacology
- Published
- 2024-12-13
- DOI
- https://doi.org/10.2174/1570159x23666241209090326
- Citations
- 3
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- Ministero della Salute