15P Verteporfin might potentiate the effects of anti-PD-1 therapy in melanoma-bearing mice model
escaping indels (AUC of 0.67 in GEL and 0.62 in HMF, vs 0.56 and 0.54 for TMB).Additional genomic features under investigation will be presented at the meeting.While initial responders had higher immune infiltrate, AR and DR tumours had comparable TME compositions.By deconvolving cell type contributions to gene expression, we found that bulk IFNg pathway expression was driven by tumour cells and was lower in DR while T cell IFNg was higher in DR patients.Conclusions: Distinct genomic and phenotypic features predict initial and durable responses to first line ICI in melanoma, suggesting separate biomarkers might be needed to accurately stratify groups.
Authors
- Zoltán Hegedüs (ORCID: https://orcid.org/0000-0001-9459-1654)
- János Tibor Fekete (ORCID: https://orcid.org/0000-0002-6672-6563)
- András Lánczky (ORCID: https://orcid.org/0000-0002-2600-7038)
- Balázs Győrffy (ORCID: https://orcid.org/0000-0002-5772-3766)
- Andrea Kovács (ORCID: https://orcid.org/0000-0002-1799-6743)
- Nabil Sayour
- L Szabó (ORCID: https://orcid.org/0000-0003-4795-6862)
- Zoltán Varga (ORCID: https://orcid.org/0000-0002-9324-798X)
- Szonja Kovacs (ORCID: https://orcid.org/0000-0001-6761-5550)
- Ágnes Paál
- Tamás Kovács (ORCID: https://orcid.org/0000-0002-1288-1592)
- Péter Ferdinandy
Institutions
- Semmelweis University (HU)
- HUN-REN Research Centre for Natural Sciences (HU)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.iotech.2024.100898
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Francis Crick Institute
- Gordon and Rose McAlpine Foundation for Neuroscience Research
- Cancer Research UK
- National Institute for Health and Care Research
- Rosetrees Trust