A Prospective Tumour Marker for Breast Cancer: YWHAB and Its Role in Promoting Oncogenic Phenotypes
We elucidate the novel role of YWHAB as a therapeutic target in BRCA, given that its inhibition mitigated aggressive phenotypes across all tumour subtypes, including triple-negative breast cancer. Furthermore, <i>YWHAB</i> emerges as a potential tumour marker, exhibiting high expression in metastatic BRCA and correlating with poor patient survival; however, it is not a sensitive blood biomarker.
Authors
- Reid Morgan Opperman (ORCID: https://orcid.org/0000-0003-2565-7976)
- Braydon Nault (ORCID: https://orcid.org/0000-0002-5209-7006)
- Lacey Winstone
- Beatrice G Gatien
- Vaishnavi L Gopaul
- Mousumi Majumder
- Sujit Maiti
Institutions
- Brandon University (CA)
Publication Details
- Journal
- Breast Cancer Targets and Therapy
- Published
- 2024-12-01
- DOI
- https://doi.org/10.2147/bctt.s479384
- Citations
- 2
- Primary Topic
- 14-3-3 protein interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.47