212P YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer
Hyperactivation of the YAP/TEAD transcriptional complex in cancers facilitates the development of an immunosuppressive tumor microenvironment. V-domain Ig suppressor of T-cell activation (VISTA) is a B7 family member that mediates the immunoinhibitory function of myeloid-derived suppressor cells (MDSCs). Yet, the expression and transcriptional dysregulation of VISTA in CRC cells is still poorly understood.
Authors
- Wanchun Tang (ORCID: https://orcid.org/0000-0003-3940-6369)
- Junying Xu (ORCID: https://orcid.org/0000-0001-6400-0606)
- Ziqing Zhu (ORCID: https://orcid.org/0000-0002-4222-2926)
- Yajuan Lv (ORCID: https://orcid.org/0000-0001-8570-5154)
- Yao Xu (ORCID: https://orcid.org/0009-0006-3504-0354)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.iotech.2024.100965
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00