226P Profiling of gastric adenocarcinomas from EU and LATAM countries identifies distinct tumor immune subgroups and a central role of the tumor microbiome in shaping the immune microenvironment
Gastric cancer (GC) is in the top list of most deadly cancers worldwide. Previous large-scale multi-omics studies have identified clinically relevant subgroups of patients. However, patients from European (EU) and especially Latin American (LATAM) countries are underrepresented in these studies. The present study, which is part of the European LEGACy project, aimed to profile the molecular and immunological features of GCs from EU and LATAM countries and explore leads for alternative treatment strategy.
Authors
- M. Cabeza Segura
- T.C. Fleitas
- C. Caballero (ORCID: https://orcid.org/0000-0001-7193-8141)
- R. Dienstmann
- Gareth I. Owen (ORCID: https://orcid.org/0000-0003-3807-6054)
- Angela Miralles
- Sarah Derks (ORCID: https://orcid.org/0000-0002-4547-7457)
- Fátima Carneiro (ORCID: https://orcid.org/0000-0002-1964-1006)
- María Maqueda (ORCID: https://orcid.org/0000-0001-9304-1714)
- Rui M. Ferreira (ORCID: https://orcid.org/0000-0003-0961-2356)
- M Garrido (ORCID: https://orcid.org/0000-0003-3399-0672)
- Judith Farrés (ORCID: https://orcid.org/0000-0002-0958-0510)
- Eloy Ruíz (ORCID: https://orcid.org/0000-0002-4644-0074)
- Arnoldo J. Riquelme (ORCID: https://orcid.org/0000-0002-8259-8960)
- F. Lordick
- Andrés Cervantes (ORCID: https://orcid.org/0000-0003-3806-3691)
- J.M.R. O'Connor
- M. Díez García
- T. van Schooten
Institutions
- Universidad Mayor (CL)
- Hebron University (PS)
- Pontificia Universidad Católica de Chile (CL)
- Universidade do Porto (PT)
- Hospital Clínico Universitario de Valencia (ES)
- Complejo Hospitalario de Navarra (ES)
- Vall d'Hebron Institut de Recerca (ES)
- IPO Porto (PT)
- Guyra Paraguay (PY)
- University Hospital Leipzig (DE)
- Instituto Alexander Fleming (AR)
- Vall d'Hebron Hospital Universitari (ES)
- CIBBIM-Nanomedicine (ES)
- Amsterdam University Medical Centers (NL)
- Instituto Nacional de Cancerología (MX)
- INCLIVA Health Research Institute (ES)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Anaxomics (Spain) (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1016/j.iotech.2024.100979
- Primary Topic
- Gastric Cancer Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Consejo Nacional de Ciencia y Tecnología
- Horizon 2020 Framework Programme