219P Radiotherapy, in conjunction with a PI3Kδ/γ inhibitor, enhances effector CD8+ T cell-mediated anti-tumor immune responses and the memory function of T cells within the tumor microenvironment by stimulating innate immunity

Retrospective investigations indicate that inhibiting PI3Kδ and/or γ, which are prevalent in leukocytes, elicits an anticancer immune response by reducing the activity of immunosuppressive cells. However, the isolated inhibition of either PI3Kδ or γ is insufficient for the complete eradication of solid tumors.