Unusual Presentation of Hyperandrogenism in Postmenopausal Women: A Report of Two Patients With Leydig Cell Hyperplasia

Hyperandrogenism is a highly prevalent and debilitating hormonal disturbance encountered in women presenting with variable phenotypical features. Causes encompass a large spectrum of tumoral and nontumoral etiologies, depending on the patients' age. We report two postmenopausal patients with an unusual etiology of hyperandrogenism. Both underwent salpingo-oophorectomy. While the first patient was cured after bilateral salpingo-oophorectomy, the second patient had residual disease after unilateral surgical management. Complete disease control was achieved after the adjunction of medical treatment. This report emphasizes the indication of bilateral salpingo-oophorectomy for the management of hyperandrogenism in postmenopausal women. A better understanding of the added value of presurgical hormonal status in further characterization of the disease phenotype is needed.