Caffeine's Neuroprotective Effect on Memory Impairment: Suppression of Adenosine <scp>A<sub>2</sub>A</scp> Receptor and Enhancement of Tyrosine Hydroxylase in Dopaminergic Neurons Under Hypobaric Hypoxia Conditions
Caffeine exhibits potent neuroprotective effects against chronic high-altitude-induced cognitive impairments, potentially through its action on A<sub>2</sub>AR, leading to enhanced TH expression and subsequent release of dopamine and its related neurotransmitters.
Authors
- Yu Wu (ORCID: https://orcid.org/0000-0002-5852-5366)
- Chaoqun Lin
- Jiaxin Xie (ORCID: https://orcid.org/0000-0002-2486-1038)
- Zhifeng Zhong (ORCID: https://orcid.org/0000-0003-2793-6178)
- Peng Li
- Huaping Dong
- Xiaoxu Li (ORCID: https://orcid.org/0000-0001-8510-624X)
- Pei Huang
- Simin Zhou (ORCID: https://orcid.org/0000-0003-2981-1192)
- Jijian Zhang
Institutions
- Army Medical University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2024-12-01
- DOI
- https://doi.org/10.1111/cns.70134
- Citations
- 8
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.26
Funders
- National Natural Science Foundation of China