Atom-economical and workup-free multiparticipation of <i>p</i>-TsOH in yne-ynamide skeletal reshuffle: access to regiospecific, chemospecific, and stereospecific (<i>E</i>)-alkenyl sulfonate/ketone-tethered indoles

This work introduces a workup-free p -TsOH-initiated yne-ynamide skeletal rearrangement process for the synthesis of stereospecific E -alkenyl sulfonate-tethered and ketone-tethered indoles via heterolytic N –Csp bond cleavage.