Knocking Down LncRNA-GAS5 Restores the Inhibition of Cuprotosis Protein FDX-1 by <i>Acinetobacter baumannii</i>

This study investigated the regulatory effect of LncRNA-GAS5 on FDX-1 in HEK293T cells by <i>Acinetobacter baumannii</i>. Transfected LncRNA-GAS5 overexpressing or knocking down plasmids into HEK293T cells, and the expression of FDX-1 was detected by Western blotting. <i>A. baumannii</i> inhibited the expression of FDX-1. Overexpression of LncRNA-GAS5 inhibited the expression of FDX-1, while knocking down LncRNA-GAS5 increased the expression of FDX-1. Overexpression of LncRNA-GAS5 further enhanced the inhibitory effect of <i>A. baumannii</i> on FDX-1, while knocking down LncRNA-GAS5 restored the inhibitory effect of <i>A. baumannii</i> on FDX-1. LncRNA-GAS5 regulates the inhibitory effect of <i>A. baumannii</i> on FDX-1 in HEK293T cells.