Transcriptomic analysis of coxsackievirus B3 infection in induced pluripotent stem cell-derived brain-like endothelial cells
Coxsackievirus B3 (CVB3) is a leading cause of viral aseptic meningitis that can produce severe disease in susceptible individuals. To gain access to the central nervous system, CVB3 must cross central nervous system barriers, such as the blood-brain barrier. Previously, we have shown that CVB3 infects a human stem cell-derived brain-like endothelial cell model. Here, we report the global transcriptome of stem cell-derived brain-like endothelial cells to CVB3 infection and provide proof-of-concept validation of the dataset using molecular biology techniques. These data could inform novel mechanisms of CVB3-mediated blood-brain barrier dysfunction.
Authors
- Sarah F. Hathcock
- Mohammad-Reza Shokri
- Robert N. Correll (ORCID: https://orcid.org/0000-0003-1453-9675)
- Jon Sin (ORCID: https://orcid.org/0000-0002-2567-3223)
- Daryl W. Lam
- Nadine Vollmuth (ORCID: https://orcid.org/0000-0002-1003-4410)
- Brandon J. Kim (ORCID: https://orcid.org/0000-0003-0476-8028)
- Julia Mamana
- Taryn E. Keyzer
- H. Mauser (ORCID: https://orcid.org/0009-0006-0080-9725)
Institutions
- University of Alabama (US)
- University of Alabama at Birmingham (US)
- Convergent Science (United States) (US)
Publication Details
- Journal
- Journal of Virology
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1128/jvi.01824-24
- Citations
- 2
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- San Diego State University
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke