Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes
The association between DHEAS and pubertal development, as reported previously, suggests a physiological connection. Our novel findings showing that DHEAS concentration correlates negatively and linearly with DNA methylation levels at regulatory regions of key puberty-related genes, provide a mechanism for such a functional relationship.
Authors
- Reinhard Stöger (ORCID: https://orcid.org/0000-0002-2301-0805)
- Philippa Melamed (ORCID: https://orcid.org/0000-0001-7814-6542)
- Gillian R. Bentley (ORCID: https://orcid.org/0000-0002-2009-5540)
- Maya Sudman
Institutions
- University of Nottingham (GB)
- Technion – Israel Institute of Technology (IL)
- Durham University (GB)
Publication Details
- Journal
- European Journal of Endocrinology
- Published
- 2024-11-27
- DOI
- https://doi.org/10.1093/ejendo/lvae156
- Citations
- 1
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Wellcome Trust
- University of Bristol
- National Institutes of Health
- Medical Research Council
- Biotechnology and Biological Sciences Research Council