Regioselectively electrochemical Csp3-H alkoxylation for functionalized indanone

An electrochemical regioselective C sp3 -H alkoxylation has been developed to synthesize functionalized 1-indanone. In this process, electricity serves as the formal terminal oxidant, while the molecular hydrogen produced by cathodic proton reduction acts as the sole by-product. This setup optimizes the economics of the oxidizing agent and contributes to the efficient production of valuable functionalized indanone. The use of mild reaction conditions and high regioselectivity makes the process highly practical. Furthermore, functionalized indanones can be synthesized through a one-pot method that involves the continuous oxidation of indan. The methodology can be easily executed on a gram scale, underscoring its potential applications. An electrochemical regioselective C sp3 -H alkoxylation has been developed to synthesize functionalized 1-indanone. In this process, electricity serves as the formal terminal oxidant, while the molecular hydrogen produced by cathodic proton reduction acts as the sole by-product. This setup optimizes the economics of the oxidizing agent and contributes to the efficient production of valuable functionalized indanone. The use of mild reaction conditions and high regioselectivity makes the process highly practical. Furthermore, functionalized indanones can be synthesized through a one-pot method that involves the continuous oxidation of indan. The methodology can be easily executed on a gram scale, underscoring its potential applications.