Next-Generation Sequencing–Based MSI Scoring Predicts Benefit in Mismatch Repair–Deficient Tumors Treated with Nivolumab: Follow-up on NCI-MATCH Arm Z1D
These genomic data highlight the importance of immune infiltration and antigen presentation in dMMR tumors that respond to immune checkpoint blockade. In addition, they suggest that, even within a dMMR population, NGS-based measures of microsatellite instability could serve as biomarkers of immunotherapy response.
Authors
- Michael J. Overman (ORCID: https://orcid.org/0000-0001-5377-135X)
- Christina Coppola
- Li Chen (ORCID: https://orcid.org/0000-0001-7973-5912)
- Jason L. Weirather (ORCID: https://orcid.org/0000-0003-0556-0616)
- Lyndsay N. Harris (ORCID: https://orcid.org/0000-0002-9774-6719)
- Jennifer Lee (ORCID: https://orcid.org/0000-0001-6630-1285)
- Jonathan D. Schoenfeld (ORCID: https://orcid.org/0000-0002-5119-0401)
- Peter James O'Dwyer (ORCID: https://orcid.org/0000-0002-9302-4073)
- Donna Brunnquell
- David R. Patton (ORCID: https://orcid.org/0000-0003-3855-0166)
- Catherine J. Wu (ORCID: https://orcid.org/0000-0002-3348-5054)
- Srin Ranasinghe
- Jacob Gross (ORCID: https://orcid.org/0000-0002-4245-1155)
- Latifa Jackson (ORCID: https://orcid.org/0000-0002-0949-978X)
- Scott J. Rodig (ORCID: https://orcid.org/0000-0003-1761-9769)
- Nilofer S. Azad (ORCID: https://orcid.org/0000-0002-9613-3988)
- Lauren Gunasti
- Katrina Kao (ORCID: https://orcid.org/0009-0009-8402-1645)
- Xiangning Bu (ORCID: https://orcid.org/0000-0002-7992-8244)
- Kathleen L. Pfaff (ORCID: https://orcid.org/0000-0003-3311-5384)
- Stanley R. Hamilton (ORCID: https://orcid.org/0000-0002-8331-1052)
- Ping Guan (ORCID: https://orcid.org/0000-0001-6672-4405)
- Victoria Wang (ORCID: https://orcid.org/0000-0003-4079-5576)
- David Sims
- Rebecca Fuchs
Institutions
- Leidos (United States) (US)
- Brigham and Women's Hospital (US)
- National Institutes of Health (US)
- City Of Hope National Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Johns Hopkins University (US)
- ECOG-ACRIN Cancer Research Group (US)
- Dana-Farber Cancer Institute (US)
- Frederick National Laboratory for Cancer Research (US)
- National Cancer Institute (US)
- Dana-Farber Brigham Cancer Center (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-0427
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00