Sirt1 blocks nucleus pulposus and macrophages crosstalk by inhibiting RelA/Lipocalin 2 axis
This study illuminates the crucial role and molecular mechanisms of Sirt1 in regulating the NP microenvironment. These insights shed light on strategies for the prevention and treatment of IVDD-related herniation and low back pain. By pinpointing specific biological targets, the screening of smallmolecule compounds with significant clinical implications can be facilitated. This translational innovation promises to optimize cells communication within intervertebral disc microenvironment via localized drug delivery, potentially improving patient outcomes and satisfaction following spinal fusion or discectomy surgeries.
Authors
- Tianyou Zhang (ORCID: https://orcid.org/0000-0001-8032-1071)
- Helong Zhang (ORCID: https://orcid.org/0000-0001-8430-6071)
- Zhiwei Li (ORCID: https://orcid.org/0000-0003-4575-5258)
- He Li (ORCID: https://orcid.org/0000-0001-6700-9286)
- Cheng Ma (ORCID: https://orcid.org/0000-0003-1248-1246)
- Tao Jiang (ORCID: https://orcid.org/0000-0002-5600-3548)
- Yongxin Ren (ORCID: https://orcid.org/0000-0001-8691-9074)
- Fenglei Yu (ORCID: https://orcid.org/0000-0003-3409-065X)
- You Lv (ORCID: https://orcid.org/0000-0003-4023-2634)
- Lingzhi Li (ORCID: https://orcid.org/0000-0002-2610-5332)
- Xin Feng (ORCID: https://orcid.org/0000-0002-0842-5471)
- Yifan Wei (ORCID: https://orcid.org/0000-0003-1245-6438)
Institutions
- Jiangsu University (CN)
- Lianyungang Oriental Hospital (CN)
- Xuzhou Cancer Hospital (CN)
- First People's Hospital of Kunshan (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1016/j.jot.2024.11.008
- Citations
- 5
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 2.24