Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promising discovery of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically determined, from Aaptos sp. collected from Bunaken National Park, Indonesia, as an anticancer agent, specifically targeting colorectal cancers (CRCs). Compound 1 showed potent cytotoxicity against DLD-1 and Caco-2 with IC50 values of 30.3 and 236.8 µg/mL, respectively. In addition, the exposure of compound 1 on those colorectal cancer cells could promote cell cycle arrest and relatively induce necrotic cell death.

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Publication Details

Journal
Acta chimica slovenica
Published
2024-12-13
DOI
https://doi.org/10.17344/acsi.2024.8779
Primary Topic
Marine Sponges and Natural Products
Type
article
Field-Weighted Citation Impact
0.00

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article

Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

Dyaningtyas Dewi Pamungkas Putri, Asep Bayu, Peni Ahmadi, A’liyatur Rosyidah et al.
Acta chimica slovenica
Marine Sponges and Natural Products
article

Aaptamine, Isolated from the Bunaken National Park’s Sponge, Aaptos sp., Promotes Cell Cycle Arrest and Induces Necrotic Cell Death of Colorectal Cancers

Dyaningtyas Dewi Pamungkas Putri, Asep Bayu, Peni Ahmadi, A’liyatur Rosyidah, Tutik Murniasih, Tri Aryono Hadi, Nurul Fatimah, Andi Setiawan, Mutia Hardhiyuna, Ucu Yanu Arbi, Masteria Yunovilsa Putra, Febby Nurdiya Ningsih, Adam Hermawan, Annisa Elcentia Fajarwati
article en

Abstract

The sponge is one of the potential sources of bioactive compounds. Among them, the sponge Aaptos has been a promising discovery of leading drugs including aaptamine (1). This study investigated the aaptamine (1), spectroscopically determined, from Aaptos sp. collected from Bunaken National Park, Indonesia, as an anticancer agent, specifically targeting colorectal cancers (CRCs). Compound 1 showed potent cytotoxicity against DLD-1 and Caco-2 with IC50 values of 30.3 and 236.8 µg/mL, respectively. In addition, the exposure of compound 1 on those colorectal cancer cells could promote cell cycle arrest and relatively induce necrotic cell death.

Acta chimica slovenicaVol. 71(4)
Saint-Gobain (France) (FR), Scottish Environment Protection Agency (GB), Centro Universitário Sant’Anna (BR), Universidad del Golfo de México (MX), Ingegneria dei Sistemi (Italy) (IT), Goodwin College (US)
Badan Riset dan Inovasi Nasional
Good health and well-being
Openalex Percentile: Top 74%
Marine Sponges and Natural Products
DOIOpen Access PDFOpenAlex
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