High-fat diet mouse model receiving L-glucose supplementations propagates liver injury
Our data indicate an increase in rate of de-novo lipogenesis (DNL) in RD-fed mice (High carbohydrate diet) and liver fibrosis following additional sugar supplementations. In contrast, HFD-fed mice (with pre-existing high lipid profile) supplemented with sugar showed less liver fibrosis, because of reduced de-novo fatty acids synthesis and subsequently, the lipid oxidation pathways become dominated and induce the net results of lipid clearance.
Authors
- Johnny Amer (ORCID: https://orcid.org/0000-0001-5828-6783)
- Shira Yochelis (ORCID: https://orcid.org/0000-0001-9180-4669)
- Yossi Paltiel (ORCID: https://orcid.org/0000-0002-8739-9952)
- Rifaat Safadi (ORCID: https://orcid.org/0000-0002-8689-5217)
- Ahmad Salhab (ORCID: https://orcid.org/0000-0003-3556-1054)
- Yuval Kolodny (ORCID: https://orcid.org/0000-0002-7656-2777)
- B. Saffouri
- Athar Amleh
Institutions
- Hebrew University of Jerusalem (IL)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2024-12-13
- DOI
- https://doi.org/10.3389/fnut.2024.1469952
- Citations
- 1
- Primary Topic
- Diet, Metabolism, and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.36