Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states
For SHH-MB cell lines in co-culture, there was a convergence of malignant cell states towards patterns of heterogeneity in patient tumors and PDX models implying these states were non-cell autonomously induced by the microenvironment. Therefore, we have generated an advanced, novel in vitro model of SHH-MB with potential translational applications.
Authors
- Max J. van Essen (ORCID: https://orcid.org/0000-0001-6168-0116)
- Alina Nicheperovich (ORCID: https://orcid.org/0000-0002-7318-9065)
- Benjamin Schuster‐Böckler (ORCID: https://orcid.org/0000-0002-8892-5133)
- Esther B. E. Becker (ORCID: https://orcid.org/0000-0002-5238-4902)
- John Jacob (ORCID: https://orcid.org/0000-0002-7285-3526)
Institutions
- University of Oxford (GB)
- Ludwig Cancer Research (GB)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1093/noajnl/vdae218
- Citations
- 4
- Primary Topic
- Hedgehog Signaling Pathway Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Ludwig Institute for Cancer Research
- Cancer Research UK
- National Institute for Health and Care Research
- University of Oxford
- Medical Research Council
- Biomedical Research Council
- NIHR Oxford Biomedical Research Centre
- Clarendon Fund