Age-dependent differences in FIB-4 predictions of fibrosis in patients with MASLD referred from primary care
Age does not relevantly modify FIB-4 predictions when using the common threshold of 1.3. Our data suggest no rationale for increasing the FIB-4 threshold to 2 for undergoing further testing in patients aged ≥65. However, the meaning of a FIB-4 of 2.7 strongly changes with age. This cutoff for ages over 65 is not enough to define high-risk and would not warrant direct referral.
Authors
- Shuen Sung (ORCID: https://orcid.org/0000-0002-4945-4797)
- Matthew Tam
- Mustafa Al‐Karaghouli (ORCID: https://orcid.org/0000-0002-0668-6002)
- Saumya Jayakumar (ORCID: https://orcid.org/0000-0001-8923-9285)
- Mang Ma (ORCID: https://orcid.org/0000-0003-2587-1788)
- Tracy Davyduke (ORCID: https://orcid.org/0000-0001-6022-7715)
- Yu Jun Wong (ORCID: https://orcid.org/0000-0002-0727-1183)
- Juan G. Abraldeṣ (ORCID: https://orcid.org/0000-0003-3421-937X)
Institutions
- Alberta Health Services (CA)
- University of Alberta (CA)
- Changi General Hospital (SG)
- Riverside Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1097/hc9.0000000000000609
- Citations
- 17
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.57