Gut microbiota-produced vitamin B6 mitigates alcohol-associated liver disease by attenuating hepatic oxidative stress damage
The imbalance of gut microbiota in ALD mice reduces vitamin B6 synthesis, which affects amino acid metabolism and glutathione synthesis in the liver, thereby exacerbating ALD. These findings suggest that vitamin B6 may play a critical protective role in ALD progression by regulating amino acid metabolism.
Authors
- Hang Shu (ORCID: https://orcid.org/0000-0002-1991-2988)
- Haiyuan Shen (ORCID: https://orcid.org/0000-0003-3520-8402)
- Linxi Xie
- Shan Gao (ORCID: https://orcid.org/0009-0006-2695-2968)
- Liangliang Zhou (ORCID: https://orcid.org/0009-0007-4942-4866)
- Shanshan Tian (ORCID: https://orcid.org/0000-0002-8670-6375)
- Xinru Zhang (ORCID: https://orcid.org/0000-0003-0643-390X)
- Long Xu (ORCID: https://orcid.org/0000-0002-0908-1797)
- Yuanru Yang
- Hua Wang (ORCID: https://orcid.org/0000-0002-2605-5697)
- Lei Yang
- Rui Ma (ORCID: https://orcid.org/0000-0002-9457-849X)
- Man Jiang (ORCID: https://orcid.org/0000-0002-3182-6863)
- Ling Jiang
- Hejiao Zhang
- Simin Yang
- Dongqing Wu
- Hao Zhang
- Yan Wang (ORCID: https://orcid.org/0009-0002-2584-9337)
Institutions
- Capital Medical University (CN)
- Anhui Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Nanfang Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1097/hc9.0000000000000599
- Citations
- 15
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 6.37