High-fat/high-sucrose diet results in a high rate of MASH with HCC in a mouse model of human-like bile acid composition
Here, we developed a new model of MASH with HCC using mice with human-like BA composition and found that HFHSD and elevated hepatic CDCA synergistically increased the risk of MASH with HCC.
Authors
- Teruo Miyazaki (ORCID: https://orcid.org/0000-0001-9796-3011)
- Hajime Ueda (ORCID: https://orcid.org/0000-0003-3983-6393)
- Tadashi Ikegami (ORCID: https://orcid.org/0000-0002-9216-3186)
- Junichi Iwamoto (ORCID: https://orcid.org/0000-0002-5238-3272)
- Akira Honda (ORCID: https://orcid.org/0000-0003-0902-8272)
- Yukio Morishita
- Takeshi Hirayama
Institutions
- Tokyo Medical University Ibaraki Medical Center (JP)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2024-12-11
- DOI
- https://doi.org/10.1097/hc9.0000000000000606
- Citations
- 4
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science