Synthesis of Primary and Secondary Amines via Electrochemical Reduction of Hydrazines
We herein introduce an electrochemical route for the N-N bond cleavage of hydrazines. This mild and green methodology utilized readily available mono- and 1,1-disubstituted hydrazines or their HCl salts as starting materials to access a broad scope of primary and secondary amines in high yields. The mechanistic investigation suggests that the amine product is formed by consecutive SET reduction, and utilization of a hydrazine HCl salt is important for providing sufficient conductivity and acidity to facilitate this reaction.
Authors
- Mingxia Liu (ORCID: https://orcid.org/0000-0002-0166-0807)
- Qiulu Wang
- Wenhui Ji (ORCID: https://orcid.org/0000-0001-9543-9240)
- Zixuan Wang (ORCID: https://orcid.org/0000-0002-8264-1121)
- Zihan Liu (ORCID: https://orcid.org/0009-0000-4573-9368)
- Jin Wang (ORCID: https://orcid.org/0000-0001-5511-1910)
- Dong Wang (ORCID: https://orcid.org/0009-0007-0760-8165)
- Yu Wang (ORCID: https://orcid.org/0000-0002-9029-1846)
Institutions
- Shandong Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-13
- DOI
- https://doi.org/10.1021/acs.orglett.4c04040
- Citations
- 6
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 1.50
Funders
- National Natural Science Foundation of China